QLS-News
QLS-scope LS
Imaging large biological tissues requires a fundamentally different optical approach than conventional high-magnification microscopy. Our QLS-Scope LS is specifically designed to handle very large samples. By combining a low magnification air objective and a zoom lens it can achieve extended fields of view while keeping a long working distance, enabling intact imaging of whole organs and large cleared specimens without sectioning.
Key Features
- Sample rotation
- Motorized XYZ stage
- Double side illumination through 2X objectives
- White light Illumination for sample viewing and OPT mode
- SPIM and multi-angle SPIM
- SPOT measuring mode for high axial resolution
- 4 laser lines
Specifications
|
Optics |
|
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Light Sheet thickness |
approx. 1 µm |
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Magnification |
0.66X – 4.64X |
|
Numerical aperture |
0.049 – 0.142 |
|
Field of view (mm) |
16.67 – 2.37 |
|
Resolving power (µm) |
6.81 – 2.35 |
|
Illumination |
|
|
Wavelength |
405, 488, 561, 640 nm Other wavelengths are also available upon request. |
|
Power |
Up to 30-65 mW, depending on the wavelength |
|
Detection |
|
|
Type |
sCMOS |
|
Pixel |
3000 x 3000 |
|
Sensor size |
11.280 x 11.280 mm |
|
Pixel size |
3.76 µm |
|
Maximum frame rate |
18 fps at full resolution |
|
Read noise |
< 3.4 e– at full resolution |
|
Cooling |
10oC with air cooling |
|
Imaging chamber |
|
|
Sample travel range (X, Y, Z) |
XYZ: 50 mm, 50 mm, 50 mm Step resolution 0.1 µm |
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Sample rotation |
Up to 360o Accuracy 0.14o |
|
Sample size |
0.1 mm to 40 mm in diameter, 40 mm in length |
|
Operation conditions |
|
|
Permissible ambient temperature |
< 35 oC, 27 oC optimum |
|
Permissible relative air humidity (no condens.) |
< 65 % at 30 °C |
|
Size |
60 x 45 x 30 cm |
|
Weight |
70 kg for imaging unit, 5 kg for power supply/PC |
Applications
Whole-Organ & Large-Tissue Imaging (Cleared Samples)
- Whole-organ cell mapping
- 3D cytoarchitecture reconstruction
- Long-range connectivity analysis (e.g. axonal tracts)
- Organ-wide gene or protein expression mapping
Pathology, Histology & 3D Diagnostics (Research Use)
- 3D histopathology (R&D / pre-clinical)
- Tumor margin visualization
- Vascular infiltration studies
- Fibrosis and tissue remodeling analysis
Developmental Biology & Organogenesis
- Embryo development (mid–late stages)
- Organ growth dynamics (fixed timepoints)
- Morphogenesis defects
- Genetic perturbation studies
Cancer Research & Tumor Biology
- 3D tumor microenvironment analysis
- Immune-cell infiltration
- Metastatic niche mapping
- Drug penetration studies
Immunology & Cell-Migration Studies
- Immune-cell spatial distribution
- Lymph node architecture
- Inflammation models
- Host–pathogen interactions
Tissue Engineering & Regenerative Medicine
- Thick organoids and assembloids
- Bioprinted tissues
- Cell-scaffold integration
- Vascularization of engineered constructs
Plant Biology & Large Botanical Samples
- Root system architecture
- Vascular transport studies
- Developmental gradients
- Stress and pathogen response